Research shows that ibuprofen may increase the risk of male fertility problems


Scientists have found that men who take high-dose ibuprofen at one time may be at greater risk of maternity problems and other health problems such as muscle consumption, erectile dysfunction and fatigue.

A study of healthy young men who took ordinary painkillers for up to six weeks showed that the drug undermined the production of male hormones and led to what commonly seen in older men and smokers.
The 18-35 year-old who took the study twice daily took ibuprofen 600 mg and within two weeks developed a condition called compensatory hypogonadism. The body must raise testosterone levels because normal testis production has dropped.

The doctor who led the study in Copenhagen said that although the volunteer’s illness was mild and temporary, they were worried that long-term use of ibuprofen could become permanent. This leads to a sustained low testosterone level because the body can no longer compensate for the fall.
David M?bjerg Kristensen of the University of Copenhagen said: “We are directly concerned with the fertility of men who have been using these drugs for a long time.” These compounds are good pain killers but are used by a number of people in the community without imagining them as appropriate Drug. ”

In March of this year, Andrei Dvorak, the former chief medical officer of FIFA, warned elite footballers that “abuse” of legal painkillers like ibuprofen is a “phenomenal trend.” Before he stepped down in November 2016, he asked the players about their use of over-the-counter painkillers and found that nearly half of the players in the last three World Cups took anti-inflammatory drugs such as ibuprofen daily.

Bernard Jégou, a senior research associate at the French National Institute of Health and Medicine, said he believes there is no problem with taking short-term ibuprofen pain relief – such as toothache – but warns not to take it, if not absolutely necessary, then by the end of the month.

Jie Gu said: “We usually see this situation in the elderly, it will cause panic.” We are very concerned about this issue, especially those who do not need to take these drugs for healthy people. Risk is greater than earnings. ”
Other researchers have warned repeatedly that ibuprofen can increase the risk of heart attacks in the general population and cause medical problems for pregnant women and infants, including more than doubling the risk of miscarriage.

In the latest study, scientists looked at the effects of ibuprofen on 31 healthy young men for more than 6 weeks and conducted further tests in the laboratory on human testicular cells and debris. Ibuprofen decreases testosterone production in the tissues, but men’s hormone levels remain unchanged. This is because the pituitary gland at the bottom of the brain has increased the level of another hormone, driving the production of additional testosterone.

Christensen said: “In the living body, the pituitary gland starts to supplement this, but the brain drives more testosterone.” “If you continue to oppress the pituitary gland for a long time, that state will become permanent and will Creating a more serious condition. “The details of the study are published in the Proceedings of the National Academy of Sciences.

William Colledge, a professor of reproductive physiology at Cambridge University, who was not involved in the study, said: “This is a very attractive study showing that men should be cautious about using high doses of ibuprofen.” In further research, he said A preventive approach makes sense. “Based on these data, I personally do not want to take ibuprofen more than the normal 10 days.”


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